generate - Generate synthetic data sets

This command generates three types of synthetic data sets for a binary classification depending on the option chosen: trivial, random or shepplogan.

trivial - Separable 3D images

This command generates a synthetic dataset for a binary classification task from a CAPS-formatted dataset. It produces a new CAPS containing trivial data which should be perfectly classified by a classifier. Each label corresponds to brain images whose intensities of respectively the right or left hemisphere are strongly decreased.

Trivial data are useful for debugging a framework: hyper parameters can be more easily tested as fewer data samples are required and convergence should be reached faster as the classification task is simpler.

Prerequisites

You need to execute the clinica run and clinicadl extract pipelines prior to running this task.

Note

The trivial option can synthesize at most a number of images per label that is equal to the total number of images in the input CAPS.

Running the task

The task can be run with the following command line:

clinicadl generate trivial [OPTIONS] CAPS_DIRECTORY GENERATED_CAPS_DIRECTORY

where:

• CAPS_DIRECTORY (str) is the input folder containing the neuroimaging data in a CAPS hierarchy.
• GENERATED_CAPS_DIRECTORY (str) is the folder where the synthetic CAPS is stored.

Options:

• --participants_tsv (str) is the path to a tsv file containing the subjects/sessions list for data generation.
• --n_subjects (int) number of subjects per label in the synthetic dataset. The number of subjects cannot be higher than the number of subjects in the baseline caps dataset. Default: 300.
• --preprocessing (str) preprocessing pipeline used in the input caps_directory. Default: t1-linear.
• --mask_path (str) Path to the atrophy masks used to generate the two labels. Default will download masks based on AAL2 in clinicadl/resources/masks.
• --atrophy_percent (float) Percentage of intensity decrease applied to the regions targeted by the masks. Default: 60.

Outputs

The command generates 3D images of same size as the input images formatted as NIfTI files. Then the prepare-data command must be run to use the synthetic data with ClinicaDL. Results are stored in the same folder hierarchy as the input folder.

random - Indissociable 3D images

This command generates a synthetic dataset for a binary classification task from a CAPS-formatted dataset. It produces a new CAPS containing random data which cannot be correctly classified. All the images from this dataset comes from the same image to which random noise is added. Then the images are randomly distributed between the two labels.

Prerequisites

You need to execute the clinica run and clinicadl prepare-data pipelines prior to running this task.

Note

The random option can synthesize as many images as wanted with only one input image.

Running the task

The task can be run with the following command line:

clinicadl generate random [OPTIONS] CAPS_DIRECTORY GENERATED_CAPS_DIRECTORY

where:

• CAPS_DIRECTORY (str) is the input folder containing the neuroimaging data in a CAPS hierarchy.
• GENERATED_CAPS_DIRECTORY (str) is the folder where the synthetic CAPS is stored.

Options:

• --participants_tsv (str) is the path to a tsv file containing the subjects/sessions list for data generation.
• --n_subjects (int) number of subjects per label in the synthetic dataset. The number of subjects cannot be higher than the number of subjects in the baseline caps dataset. Default: 300.
• --preprocessing (str) preprocessing pipeline used in the input caps_directory. Default: t1-linear.
• --mean (float) Mean value of the gaussian noise added to images. Default: 0.
• --sigma (float) Standard deviation of the gaussian noise added to images. Default: 0.5.

Outputs

The command generates 3D images of same size as the input images formatted as NIfTI files. Then the extract command must be run to use the synthetic data with ClinicaDL. Results are stored in the same folder hierarchy as the input folder.

shepplogan - 2D slices of heterogeneous classes

This command is named after the Shepp-Logan phantom, a standard image to test image reconstruction algorithms.

It creates three subtypes of 2D images distributed between two labels. These three subtypes can be separated according to the Top (framed in blue) and Bottom (framed in orange) regions: - subtype 0: Top and Bottom regions are of maximum size, - subtype 1: Top region has its maximum size but Bottom is atrophied, - subtype 2: Bottom region has its maximum size but Top is atrophied.

These three subtypes are spread between two labels which mimic the binary classification between Alzheimer's disease patients (AD) with heterogeneous phenotypes and cognitively normal participants (CN). Default distributions are the following:

subtype	0	1	2
AD	5%	85%	10%
CN	100%	0%	0%

The CN label is homogeneous, while the AD label is composed of a typical subtype (1), an atypical subtype (2) and normal looking images (0).

Prerequisites

There are no necessary prerequisites to run this pipeline.

Running the task

The task can be run with the following command line:

clinicadl generate shepplogan [OPTIONS] GENERATED_CAPS_DIRECTORY

where GENERATED_CAPS_DIRECTORY (str) is the folder where the synthetic CAPS is stored.

Options:

• --n_subjects (int) number of subjects per label in the synthetic dataset. Default: 300.
• --image_size (int) is the size in pixels of the squared image. Default: 128.
• --cn_subtypes_distribution (Tuple[float, float, float]) are the ordered probabilities of each subtype to be drawn in CN label. Default: (1.0, 0.0, 0.0).
• --ad_subtypes_distribution (Tuple[float, float, float]) are the ordered probabilities of each subtype to be drawn in CN label. Default: (0.05, 0.85, 0.10).
• --smoothing / --no-smoothing adds random smoothing to generated data. Default will not smooth data.

hypo-metabolic -

Prerequisites

Running the task

The task can be run with the following command line:

clinicadl generate hypometabolic [OPTIONS] CAPS_DIRECTORY GENERATED_CAPS_DIRECTORY

where: - CAPS_DIRECTORY (str) is the input folder containing the neuroimaging data in a CAPS hierarchy. - GENERATED_CAPS_DIRECTORY (str) is the folder where the synthetic CAPS is stored.

Options:

• pathology
• pathology_percent
• --participants_tsv (str) is the path to a tsv file containing the subjects/sessions list for data generation.
• --n_subjects (int) number of subjects per label in the synthetic dataset. Default: 300.